A 92-year-old man with end-stage glaucoma who had previously developed allergic contact dermatitis while using topical brimonidine developed a second episode of dermatitis on rechallenge (A). The inflammation rapidly resolved after discontinuation of brimonidine, but at his next follow-up visit, he complained of new-onset, bilateral periocular depigmentation (B). The patient’s age, lack of any history of autoimmunity, and the localized distribution of his lesions suggested a medication-induced process rather than vitiligo. We believe that this patient’s symptoms are most likely due to post-inflammatory hypopigmentation, a rare but well-documented sequela of allergic contact dermatitis.