A 6-week-old non-Hispanic white boy presented to the Neonatal Intensive Care team of Tulane University Medical Center with a 3-week history of yellow-grey discharge from both eyes; he was otherwise in no distress. He was born by normal vaginal delivery at 37 weeks gestational age after an uneventful pregnancy. He was in the care of foster parents, and the medical history of his biological parents was unknown. There was no other ocular history. He had no known allergies, and his immunizations were up-to-date. He had pulmonary hypertension, a patent ductus arteriosa, and had undergone repair of a diaphragmatic hernia at 1 week of age. For 4 days prior to presentation, he had been administered erythromycin elixir, 400 mg orally four times daily, without improvement in ocular discharge.