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Pathology Quiz 11: Histopathology of a lacrimal gland
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Wasee Polcharoen, M.D. | Massachusetts Eye and Ear Infirmary, Harvard Medical School Mehran A. Afshari, M.D., M.P.H. | Massachusetts Eye and Ear Infirmary, Harvard Medical School February 10, 2000
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Figure 1
Histopathology of a lacrimal gland mass FROM a 40-year-old man demonstrating a mixture of double-layered epithelial units and a myxoid stroma (H&E stain)
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| Questions and Answers | 1. What is the pathologic diagnosis?
Answer: Pleomorphic adenoma (Benign mixed tumor).
2. What is the most common presenting symptom of this lesion?
Answer: A painless, slowly developing mass in the lacrimal gland region that is generally well tolerated and rarely produces symptoms of pain, diplopia, or visual loss. Examination shows proptosis, downward and inward displacement of the eyeball.
3. What are the radiologic findings of this lesion?
Answer: A pressure indentation and accentuation of the lacrimal fossa. The tumor mass is usually rounded and ovoid, and frequently flattening the sclera.
4. What is the appropriate treatment of this lesion?
Answer: A lateral orbitotomy and complete excision of the tumor within its capsule (en bloc excision).
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